Using some basic search logic you can take your PICO question's main concepts of Population, Intervention, and Comparison and plug them into a formula to create a search that will work on most of the disciplinary research databases.
One of the most basic formulas that you can use to make a PICO question work is:
Population AND (Intervention OR Outcome)
in some cases, a population may be more complicated to conceptualize, so here's an example:
"Children with anxiety" AND (medication OR "cognitive behavioral therapy")
because of how this search may turn out, however, we want to think about how to conceptualize our population. Anxiety can be classified a few different ways in medical and psychological literature, so it is important to separate between anxiety as a feeling and anxiety as a disorder. Similarly, with EBP it is often good to become specific with a population if possible, as the medical and psychological communities will divide children into age groups for study purposes.
("School-aged Children" AND "anxiety disorders") AND (medication OR "cognitive behavioral therapy")
If you noticed above, i used AND, OR, parentheses, and quotation marks. These are universal ways that can help make your search more effective.